Biologists criticize Fable over strict Mythos biology guardrails

Academic researchers have raised concerns over newly implemented biological safety guardrails on Fable's Mythos platform. According to user reports, the AI system now outright rejects all prompts containing biological terminology, including benign tasks such as non-human genome assembly and annotation. Critics argue that while preventing biosecurity threats is vital, Fable's blanket ban disproportionately harms underfunded laboratories that cannot afford specialized, unrestricted access tiers. Researchers are calling on Fable to implement more granular, risk-based safeguards targeting specific high-risk areas like immunology, drug design, and genetic engineering, rather than blocking the entire field of biology. Fable has not yet publicly responded to complaints regarding these restrictive filters, which users claim are disrupting standard scientific workflows.